Publications

Using Centrifugation in Cell Therapy Manufacturing

Primary Clarification of CHO Cells with Single-Use Centrifuge Technology

Until the advent of single-use centrifugation, there was little choice for the primary clarification step within single-use bioprocesses. With the arrival of the single-use centrifuge, bioprocessing development engineers again have a choice in primary clarification technology.

Single-Use Centrifuges Are Transforming Biopharmaceutical Development and Manufacturing

Single-use equipment has become universally accepted and used for the manufacturing of clinical and licensed drug products. Download this whitepaper and learn more about the benefits of single-use technologies, and the important features to provide fast processing times, low-shear performance and high product recovery in a scalable platform.

Optimizing Washing Efficiency in Cell Washing and Media Exchange for Cell Therapy Manufacturing

In this case study we present data demonstrating the performance of a single-use centrifuge (CARR Biosystems’ UniFuge® family) in cell washing.

Clarification of CHO Cells with the UFMini

In biomanufacturing, clarification is the process of removing cells and cellular debris from the liquid contents of a bioreactor. Centrifugation is a popular choice in the biomanufacturing industry for use in primary clarification. Turbidity sampling is often used in biomanufacturing as a tool to measure the efficiency of a clarification process. Performance of the UFMini single-use centrifuge was evaluated for the clarification of CHO-S cells as measured by supernatant turbidity and cell viability.

Cell Harvesting: Optimizing Viability and Recovery in Cell Therapy

The cell harvesting step is of utmost importance for cell therapy manufacturers. During this step, high cell viability and recovery are important to maximize yield. Single-use, low shear closed-system centrifuges enable safe and efficient cell therapy manufacturing through the efficient recovery of viable cells.