PowerFuge® P6: A Stainless Steel System for Automated Solid-Liquid Separation
Maximize yield with the high-throughput processing power of the PowerFuge P6. Handle high-density feeds and automate solids removal with CIP/SIP cycles to enhance efficiency and reliability in large-scale production.
| Minimum Working Volume 1.1 L | Flow Rate 1 L/min | G-force Up to 20,000 xg |
Benefits of CARR Biosystems PowerFuge P6
Versatility
Transition from development to manufacturing, handling applications like E. coli harvest, lysate removal, P. pastoris clarification, specialty chemicals, and solvent separations.
Performance
Handle even the most challenging separations with the ability to process bacteria, fungi, proteins, and submicron particles using 20,000xg separation force.
Durability
Reduce downtime and maintenance costs with robust construction, high-quality materials, comprehensive maintenance, and CIP/SIP capabilities, ensuring fewer parts to replace and longer operational life.
Reliability
Integrate into cGMP, chemical, and pharmaceutical industry protocols, with consistent and reliable performance for critical applications with stringent regulatory standards.
The PowerFuge P6 is a high-performance automated centrifuge for efficient liquid-solid separation. Its titanium-alloy tubular bowl enables low-shear separation of bacterial, fungal, protein, and submicron particles. The PowerFuge P6 produces a dry cake for a product yield of up to 98% and handles high-density feeds without dilution.
- Complete liquid/solid separations
- Full Clean-In-Place/Sterilize-In-Place (CIP/SIP)
- Fully automated processes including solids removal
- Integrated cooling jacket
- Regulatory documentation available
- Closed processing system
| Rec. Processing Volume | 1.1 L minimum |
| Max Flow Rate | Up to 1 L/min for batches up to 100 L |
| Rotational Force | Up to 20,000 xg |
| Max Concentrate Density | <1.5 g/ml |
| Weight | 700-1,000 kg (1,500-2,200 lbs) |
| Maximum Case Pressure | 6.9 bar (100 psi) |
| Programmable Logic Controllers (PLC) | Allen-Bradley® or Siemens® |
| Feed | Feedcone acceleration |
| Electrical Requirements | 400V/50Hz or 480V/60Hz |
| Pneumatic | Clean, dry air supply 6 bar (90 psi), 566 Standard Liters per Minute (SLPM), 20 Standard Cubic Feet per Minute (SCFM), Instrument-quality air only, supplied at 80-100 psi |
Process Wetted Parts Construction
- 316 and 316L stainless steel
- 17-4 PH stainless steel
- Nitronic 60 stainless steel
- High-strength titanium alloy
- Teflon, silicone, ethylene propylene diene monomer (EPDM) O-rings and gaskets
- Stainless steel finish: electropolish (25 RA)
- Titanium alloy bowl tumbled finish: (25 RA)
- Swinglock rollers of polyether ether ketone (PEEK) thermoplastic
The PowerFuge is a continuous flow centrifuge that introduces the feed through a stationary pipe and accelerates it to full rotational speed before entering the titanium-alloy tubular bowl. Centrifugal forces separate solids from liquids, compressing solids against the bowl wall while the supernatant flows into a collection chamber. Compressed solids are periodically removed with a fully automated scraping cycle.
The PowerFuge P6 features:
- Fully automated, intuitive software accessible through Allen-Bradley or Siemens HMI touchscreen
- Optional hazardous duty (Class 1, Div 1, Group C and D) and CE configurations available
- Designs available for ASME-rated boundary, hazardous locations, and aseptic operations
Endorsements
See What People Are Saying About Our Stainless Steel Centrifuges
“The explosion-proof PowerFuge closed up our solvent process for a safe and environmentally friendly manufacturing method.”
Senior Process Engineer, Pigments
“The PowerFuge closed up our ethanol process and its automatic scraping improved our recovery.”
Associate Director of Vaccine Franchise
“Removing large particles with PowerFuge reduced the number of filtration steps.”
Manufacturing Engineer, Pigments
“The high g-force of the PowerFuge [e. Coli lysate clarification] reduced our downstream clarification needs.”
Senior Process Development Scientist, pDNA
"Gentle handling of our cells at scale resulted in higher VLP recovery.”
Director of Operations, Vaccine Manufacturing
Scale up or down with PowerFugeⓇ
Our PowerFuge family enables efficient liquid-solid separation. Its durable stainless steel construction handles bacteria, fungi, proteins, and submicron particles from small to large-scale applications.
Featured Resources
Frequently Asked Questions (FAQs)
What types of applications is the PowerFuge P6 suitable for?
The PowerFuge P6 is suitable for a wide range of applications, including E. coli whole cell harvest, lysate removal, inclusion bodies, P. pastoris clarification, specialty chemicals such as aluminum flake and carbon black, and solvent separations including ethanol and ethyl acetate.
Can the PowerFuge P6 be used in hazardous environments?
Yes, the PowerFuge P6 can be configured for hazardous duty environments and has designs available for CE Marking and SIP, making it suitable for safe operation in various challenging conditions.
Is the PowerFuge P6 scalable to smaller or larger production volumes?
The PowerFuge P6 is part of a scalable platform that includes smaller models like the PowerFuge Pilot and larger models such as the P12 and P18, allowing for seamless scale-up or scale-down to meet production volume requirements.
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