Publications

Scaling Primary Clarification with Tubular Bowl Centrifugation

Addressing the Complexities and Challenges in Lentivirus Harvest Clarification

Navigating the Challenges of iPSC Differentiation: The Advantages of Tubular Bowl Centrifuges in Media Exchange

Efficient FBS Removal and Cell Concentration in Vero Cell Cultures

The study explored the application of the CARR Biosystem’s UFMini to achieve concentration and FBS removal from Vero cell cultures using PBS as the wash solution. The UFMini’s capability to concentrate and wash Vero cells efficiently while preserving their viability in a closed, automated system underscores its potential for optimizing Vero cell culture processes.

Clarification of HEK293 Cells Using Centrifugation: Results from the UniFuge® Pilot and the UFMini

This case study presents data from the CARR Biosystems team highlighting the UniFuge family and the ability to clarify HEK293 cells in a manner yielding better results than other forms of filtration.

Single-Use Systems Boost Viral Titer from HEK293 Cell Culture

Depth filtration has become a trusted standby for scientists and engineers looking to separate viral vectors – a popular delivery system for gene-based therapies and vaccines – from the HEK293 cell culture in which they’re typically grown. But as emerging therapies advance from the lab and into the clinic, and viral vector production demands rise to fuel these therapies, relying on depth filtration alone to clarify HEK293 cell culture and collect viral titer becomes too labor-intensive, costly, and inefficient to make for a seamless scaling-up transition. In this case study, we show how the UFMini single-use centrifuge significantly reduces filtration needs and drastically enhances the amount of viral titer collected when compared to conventional methods.