High Cell Recovery
- Efficient recovery of viable cells to maintain potency and yield
- Gentle, low-shear processing minimizes cell damage, preserving viability
Vaccines
Enhance vaccine production with UniFuge®, ViaFuge®, and PowerFuge®. These centrifuges are designed for reliable, scalable vaccine development, offering flexibility for both live virus and recombinant vaccines.
How It Works
One cell processing platform for the full cell therapy development cycle
CARR’s centrifuge platforms use tubular bowl technology for gentle, low-shear separation, crucial for preserving cell viability in live virus vaccines and removing debris in recombinant vaccines. UniFuge and ViaFuge handle live virus applications, while PowerFuge manages complex solids in traditional vaccine production. All models support reliable, contamination-free processing.
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Cell BankingSecurely harvests and stores high-viability cells for future vaccine production, ensuring consistent quality and reproducibility across batches. | Gene EditingSupports efficient recovery of genetically modified cells, critical for vaccine production involving gene-edited viral vectors or recombinant proteins. | Seed TrainScalable processing efficiently separates and concentrates cells, preparing them for transfer to larger bioreactors for further expansion. |
IntensificationMedia exchange and optional washing maintain cell health for n-1 intensification, enabling advanced manufacturing strategies. | Live Virus HarvestLow-shear processing with UniFuge and ViaFuge maximizes viable cell recovery, preserving the integrity of sensitive virus cultures during harvest. | Recombinant Vaccine HarvestPowerFuge ensures high recovery and purity of recombinant proteins, minimizing impurities while maintaining product quality for protein-based vaccines. |
Key Benefits
Benefits of using CARR Biosystems for Vaccines
Optimized Solid Handling
- Ability to process challenging materials like polysaccharides and recombinant proteins
- High-G force enables effective clarification of sub-micron particles
Closed System Processing
- Closed-system design reduces contamination risks for safe vaccine production
- Safely handles hazardous processing of materials like ethanol
Enhanced Versatility
- Products to support both live virus and recombinant protein vaccine production
- Provide consistent results across various vaccine types and production stages
Endorsements
See what people are saying about Vaccines
“The PowerFuge closed up our ethanol process and its automatic scraping improved our recovery.”
Associate Director of Vaccine Franchise
“We replaced our bottle centrifuges with a single continuous ViaFuge, saving cleaning, autoclaving, and manual manipulations."
Animal Vaccine Manufacturing Operations Manager
"Gentle handling of our cells at scale resulted in higher VLP recovery.”
Director of Operations, Vaccine Manufacturing
Centrifuges
Select your centrifuge platform
Frequently Asked Questions (FAQs) About Vaccines
How do CARR centrifuges handle hazardous processing and difficult materials?
CARR centrifuges’ closed system design enables hazardous processing like ethanol drying and handles challenging materials such as fumed silica. During ethanol drying for polysaccharide production, the closed system minimizes exposure and risk. For difficult solids like fumed silica, CARR centrifuges are engineered to prevent clogging and ensure smooth, continuous operation.
What are the key advantages of tubular bowl centrifugation for vaccine production?
Tubular bowl centrifugation offers gentle separation of cells and solids, which is crucial for maintaining cell viability in live virus vaccines and efficiently removing debris in recombinant vaccine production.
How scalable are CARR centrifuge systems for vaccine production?
CARR centrifuge systems are designed to scale seamlessly from small-scale research to large-scale manufacturing. The UniFuge platform offers single-use options that support flexible volumes, ranging from small batches with the UFMicro to large production runs with the UniFuge U2K. For even higher throughput, the PowerFuge and ViaFuge stainless steel centrifuges handle volumes up to 2,400 L/hr, providing high yield and consistent performance across all production scales.
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