Publications

UniFuge® Cell Processing Platform

Navigating the Challenges of iPSC Differentiation: The Advantages of Tubular Bowl Centrifuges in Media Exchange

Achieving Optimal Cell Harvest for Allogeneic Therapies with Purpose-Built Harvest Technologies

Cell harvesting is crucial to the cell therapy manufacturing process, bridging the gap between cells’ optimized growth environment and a final formulation that retains their potency and efficacy. The number of variables that impact harvesting, coupled with the complexities introduced by the unique CQAs of each cell therapy and the fragility of many emerging cell types, can result in a challenging balancing act that requires significant expertise to navigate.

Primary Clarification of Lentiviral Vector with Low-Shear Separation

Lentiviral vectors are commonly used in the production of ex vivo cell therapies to transduce various cell types. Lentiviral vectors are sensitive to the shear forces of traditional continuous centrifugation systems. Additionally, significant yield losses due to adsorption effects can be seen during the primary clarification of lentiviral vectors with single-use filtration methods such as depth filtration.

Using Centrifugation in Cell Therapy Manufacturing

Single-Use Centrifuges Are Transforming Biopharmaceutical Development and Manufacturing

Single-use equipment has become universally accepted and used for the manufacturing of clinical and licensed drug products. Download this whitepaper and learn more about the benefits of single-use technologies, and the important features to provide fast processing times, low-shear performance and high product recovery in a scalable platform.