High Cell Recovery
- Efficient recovery of microbial cells for downstream workflows
- Gentle, low-shear processing preserves cell integrity and product yield
Microbial Fermentation
Streamline microbial fermentation workflows with high-performance centrifuge solutions designed for diverse applications. PowerFuge®, UniFuge®, and ViaFuge® deliver scalable, efficient separations for both intracellular and extracellular products.
How It Works
Scalable, tunable technology for diverse microbial products
CARR’s centrifuge platforms use tubular bowl technology for efficient microbial fermentation separation, including E. coli, yeast, bacteria, and fungi. From secreted proteins to dense intracellular products, these systems adapt to unique workflow needs with tunable parameters and closed-system operation to minimize contamination risks.
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Cell BankingThe closed system harvests and concentrates microbial cells, performing media exchange to reduce contamination risk during cryopreservation. |
Cell Harvest for Intracellular ProductsGentle separation concentrates microbial cells, preserving intracellular product integrity for downstream recovery and processing. |
Inclusion Body HarvestTunable parameters enable precise separation and concentration of dense, insoluble inclusion bodies, optimizing recovery for challenging workflows. |
Secreted Products and ClarificationEfficient separation removes cell debris, clarifying supernatant for secreted products and ensuring a clean process for downstream steps. |
Post-Lysis ClarificationLow-shear separation removes cellular debris after lysis, maximizing recovery and preserving the integrity of valuable intracellular components. |
IntensificationMedia exchange and optional washing maintain microbial culture health, enabling high-density workflows and advanced manufacturing strategies. |
Key Benefits
Benefits of using CARR Biosystems for Microbial Fermentation
Optimized Solid Handling
- Handles challenging microbial products like inclusion bodies and proteins
- High-G force enables clarification of dense and insoluble materials
Closed System Processing
- Closed-system design minimizes contamination risk during microbial processing
- Supports safe handling of high-density cultures and hazardous materials
Versatile Product Processing
- Processes soluble, insoluble, intracellular, and extracellular microbial products
- Tunable parameters adapt to diverse physical and biochemical properties
Endorsements
See what people are saying about Microbial Fermentation
“Removing large particles with PowerFuge reduced the number of filtration steps.”
Manufacturing Engineer, Pigments
“The UniFuge was easy to scale-up, and the Viafuge enables us to recover viable cells at large scale, beyond what single-use can typically accomplish."
Cellular Agriculture Entrepreneur
Centrifuges
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Frequently Asked Questions (FAQs) About Microbial Fermentation
What types of microbial products can CARR centrifuges handle?
Our centrifuges process a wide range of microbial products, including E. coli, yeast, bacteria, and fungi. They are designed to manage secreted products, intracellular products, and dense inclusion bodies with precision and efficiency.
Which centrifuge is best for large-scale microbial workflows?
The PowerFuge is ideal for large-scale workflows due to its high throughput, robust G-force for challenging separations, and automated solids handling. It efficiently processes dense cultures and inclusion bodies, making it perfect for industrial-scale microbial fermentation.
How do these centrifuges ensure gentle processing for microbial products?
Using tubular bowl technology, these centrifuges provide low-shear separation that preserves the integrity of sensitive microbial products. This gentle processing is crucial for maintaining cell viability and recovering intracellular or extracellular components.
How do CARR centrifuges support workflow intensification in microbial fermentation?
Our centrifuges enable workflow intensification by performing critical steps such as media exchange and washing in a closed system. This maintains optimal culture conditions by removing waste products and replenishing essential nutrients, allowing for higher cell densities and improved productivity. These capabilities are particularly valuable for advanced manufacturing strategies, where maximizing efficiency and yield are critical to scaling microbial fermentation processes.
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