Enhanced Cell Viability
- Low-shear separation to preserve cell health
- Efficient cell washing and buffer exchange to remove spent media or reagents
- Optimal cell reproduction rates through gentle processing
Cellular Agriculture
Optimize cell agriculture workflows with versatile, gentle cell handling for consistent scalability and efficiency. Achieve high viability and tunable processing from lab to full-scale production with the UniFuge® single-use platform and ViaFuge® for SIP/CIP applications.
How It Works
Versatile, high-throughput centrifuge solutions for cell agriculture production
UniFuge and ViaFuge centrifuges use low-shear, tubular bowl technology to preserve cell health, promoting high reproduction rates and improved viability. The UniFuge supports versatile scale-down for development, while the ViaFuge, designed specifically for cell agriculture and perfusion, provides automated, non-disposable, high-throughput processing, making both models adaptable for various stages of production.
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Gene EditingGentle separation concentrates cells and exchanges media, preserving cell integrity for efficient gene editing. |
Cell ExpansionLow-shear separation supports high cell reproduction rates, allowing cells to expand without compromising viability. |
Perfusion & Media ExchangeContinuous perfusion and automated exchange maintain optimal conditions by removing waste and refreshing media. |
Continuous HarvestLow-shear, continuous harvesting maintains cell viability while enabling uninterrupted downstream processing for efficient workflows. |
Cell HarvestCareful separation gently concentrates cells, minimizing damage with optional washing to enhance purity. |
Cell Banking & StorageGentle handling prepares cells for storage, ensuring high viability and reducing contamination risks during future use. |
Key Benefits
Benefits of using CARR Biosystems for Cellular Agriculture
Increased Throughput
- High g-force capabilities allow faster processing without cell damage
- Efficient concentration for streamlined downstream processing
- Faster processing times reduce overall production cycle
Seamless Scalability
- Seamless scalability with tunable process parameters to support development to manufacturing
- Automated processes with quick setup in under 15 minutes
- 21 CFR Part 11 compliant
Application Versatility
- Stainless steel and single-use models for flexible solutions
- Suitable for perfusion, harvesting, and banking across cell types and densities
- Compatible with different production scales for seamless integration
Data Highlights
High recovery and cell health in cell agriculture
Cell Viability and Recovery
The UniFuge Pilot and UniFuge Mini deliver over 98% cell recovery with less than 5% viability loss in bovine cells, demonstrating efficient cell intensification with gentle processing and supporting similar results across various cell types.
Cell Health and Integrity
The UniFuge Pilot maintains cell integrity through low-shear processing, reducing LDH release to under 1%. This is significantly lower than traditional disk stack systems, which produce up to 12.5% LDH, which indicates cell stress.
Case Study
Single-use centrifuges achieve >90% recovery with minimal loss in cultured meat
The Challenge
The cell agriculture industry requires scalable methods to gently harvest and clarify various animal cells (e.g., chicken, salmon, bovine) from complex growth media without compromising cell viability or recovery.
The Solution
CARR Biosystems collaborated with cell agriculture scientists to test the UniFuge platform in optimizing cell harvesting parameters for different cell types. By adjusting the feed rates and g-forces, the centrifuges were evaluated for compatibility with different cell densities and production needs.
The Outcome
The UniFuge platform delivered:
- High recovery: 90% to 95% recovery across tested conditions.
- Low cell damage: Viability loss remained below 5% for all tests.
- Minimal LDH generation: Less than 1% LDH release with the UniFuge Pilot, significantly lower than disk stack alternatives.
Endorsements
See what people are saying about Cellular Agriculture
“The UniFuge was easy to scale-up, and the Viafuge enables us to recover viable cells at large scale, beyond what single-use can typically accomplish."
Cellular Agriculture Entrepreneur
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Frequently Asked Questions (FAQs) About Cellular Agriculture
What cell recovery rates can be achieved with CARR’s centrifuges?
CARR’s centrifuges, including the UniFuge and ViaFuge series, are designed to achieve high recovery rates, often exceeding 90% depending on the specific cell type and process parameters.
How does the centrifuge maintain sterility during processing?
CARR centrifuges, available in both single-use and stainless steel models, are designed to minimize contamination risks. The single-use UniFuge platform offers a closed, contamination-free environment, ideal for sterility-sensitive applications. For stainless steel models, like ViaFuge, features like clean-in-place (CIP) and steam-in-place (SIP) ensure effective sterilization and support ongoing sterility in continuous production environments.
Are CARR’s centrifuge models scalable?
Yes, CARR’s UniFuge series supports scalability from small-bench scale through to pilot and full-scale production. The range of models allows users to develop processes at smaller scales and seamlessly scale up to higher capacities.
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